Features

Maximizing Reliability, Minimizing Down Time

Fully Unattended Operation from Startup to Shutdown

Nexera can be set to start up at a specified time, so that it can complete auto-purge, equilibration and baseline checks in advance, and be ready for analysis as soon as you arrive at the lab. Moreover, the system can be set up in advance to run without user intervention all the way from start up through analysis to shutdown. You can view the status and predicted analysis completion time for multiple systems from any location via a smart device. None of these features requires any special software.

Auto-Diagnostics and Recovery

In rare cases, air bubbles can form in the mobile phase and cause problems if inhaled into the pump. Nexera has the ability to monitor baseline changes and pressure fluctuations to check for abnormalities. When it detects an unusual fluctuation, it can automatically pause the analysis, purge the flow path, and restart analysis once it has confirmed recovery to normal pressure.

FlowPilot Protects Columns

HPLC columns can be damaged by sudden pump starts and stops or extreme gradient changes. The Nexera automatically uses FlowPilot (Smart Flow Control) to increase the flow rate gradually to the set point. There is no need to create startup protocols for each analysis.

Mobile Phase Levels Measured in Real Time

Reservoir tray weight sensors (optional) can be used to monitor the volume of mobile phase or autosampler rinse solution in up to twelve containers. The containers can also be checked remotely from a smart device.
You will no longer need to worry about running out of mobile phase mid-analysis, because the device will notify you before starting the run if the volume remaining is too low.

Remote Monitoring and Integrated Lab Management

Reliably Track Column Usage*

Columns used in analysis need to be traceable to investigate any influence they may have on results. With the Column Management Device (optional), each column is recognized by an individual ID, and stats such as pressure and injection number are automatically recorded in the database and linked to each measurement data file. The device can be linked to all columns regardless of their brand or type. The condition of a column can be checked directly with the column management software, so that you can start analysis without having to test column performance in advance. *To make use of this feature, a CMD compatible with the Nexera series and LabSolutions DB/CS are required.

Check Chromatograms Online

View the operating status of instruments from a web browser using a smart device. This allows you to confirm parameters such as oven temperature and pump status directly from the web, and to monitor chromatograms in real time without returning to the lab. In addition, SHIMADZU LabTotal™ Smart Service Net (optional) saves operating data from your instruments in a cloud server. Error information, including the date and time the errors occurred, can be sent via email.

Allocate Resources Efficiently

Manage the overall operation of your lab with SHIMADZU LabTotal Smart Service Net (optional). Review and compare instrument usage to maximize available analysis time, and manage shared consumables through a common system. (Patent Pending)

Automating Workflow, Maximizing Throughput

Analysis Cycle Time Less Than 10 Seconds

The SIL-40 autosampler can process the entire injection cycle time in as little as seven seconds, twice as fast as the previous model. In addition, continuous analysis can be carried out on up to 44 MTPs (using 3 PLATE CHANGERS). Together these features dramatically increase analysis throughput. Pharmacokinetic analysis requires not only speed but also high reliability at low concentrations. With its ultra-fast injection and ultra-low carryover, the SIL-40 autosampler delivers high reproducibility and reliability, even during an ultra-fast 30-second analysis.

Remote Instrument Maintenance Ensures Stable Operation

Each Nexera component automatically transfers the status of consumable parts, the traceability information of consumable parts after shipment from the factory, and various logs and error information to the SHIMADZU LabTotal Smart Service Net cloud system. Using this information, the system recommends the timing for consumable part replacement. Problems can be diagnosed remotely by Shimadzu service engineers. This means the system can be maintained in optimal condition and equipment management costs can also be reduced.

Compact and Inventive

Space-Saving Design.

The Nexera frees up bench space with a compact design two thirds the size of Shimadzu's previous model.

Energy-Saving Standby Mode

The Nexera uses over 80% less electricity when in standby mode, significantly reducing running costs and supporting an environmentally-friendly lab.

Dual Injection Enables Simultaneous Analysis

Injection ports for two separate flow paths can be installed, allowing two different types of analysis (such as analysis of amino acids, organic acids or vitamins) to be performed using one system.

Intuitive touch panel

The large LCD touch panel on the SCL-40 system controller removes the need for a PC. As well as controlling the instrument and checking the analysis status, you can monitor chromatograms directly from the display. Note: If you prefer to link the system to a PC, the touch panel feature can be turned off. Please inform the service staff during system installation.

Stable Baseline

Baseline fluctuations can affect peak area calculation, reducing the accuracy of quantitative results. The SPD-M40 photodiode array detector’s “Advanced TC-Optics” function adjusts the temperature of the flow cell, lamp, and optical system to lessen the impact of external temperature changes. Noise and drift have also been reduced by 40% compared to the previous model.

High-Sensitivity Impurity Analysis

The SPD-M40 detector achieves an extremely high level of sensitivity and linearity (up to 2.5 AU). This allows quantitation of very lowconcentration impurities even in high-concentration samples. The UV cut-off filter installed in the detector prevents sample degradation due to UV light, helping to maintain good linearity at low concentrations.

Improvement of Quantitative Performance using UV Cut-Off Filter on SPD-M40

The UV cut-off filter resulted to be useful for quantitative determination of components that are easily degraded by wavelengths in the UV range, particularly improving quantitation accuracy in the low concentration range.

Superb injection precision over a wide range of volumes

Obtain highly reliable data with the SIL-40 autosampler series, which provides excellent precision over all its injection volume settings for different column sizes and sample volumes.

Unique design to ensure reliable sample cooling

The SIL-40 series has a “direct access” function which allows extra sample vials or MTPs to be added even during analysis. Dry air flow control maintains the temperature inside the autosampler and protects the samples from condensation.

Thanks and Regards,

“Advance Science Family”